Article

US researchers have developed ReForm, an artificial metabolism system that converts CO₂-based molecules into usable chemicals like acetyl-CoA, using newly engineered enzymes and a cell-free synthetic biology approach. This innovative system bypasses traditional metabolic pathways found in living organisms, demonstrating the ability to further convert acetyl-CoA into malate and explore other CO₂ substrates. While still in the laboratory phase, the team aims to optimize ReForm for improved yields and new enzyme designs.