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In Q4 2025, Philippe Laffont exited CoreWeave Inc, selling 6,724,615 shares, impacting his portfolio by -2.26%. He added significant stakes in MasTec Inc, Vertiv Holdings Co, and Rocket Companies Inc, while increasing holdings in Applied Materials Inc and Natera Inc.

Laffont also reduced positions in PayPal Holdings Inc and Meta Platforms Inc. As of Q4 2025, his portfolio consisted of 52 stocks, with top holdings in Taiwan Semiconductor Manufacturing Co Ltd, Microsoft Corp, and Meta Platforms Inc.