Article

A research team from Nankai University, Sichuan University, and Zhejiang Normal University developed a novel visible light-driven catalytic strategy for deracemization of α-aryl cyclic ketones using photocatalysis, hydrogen atom transfer, and chiral phosphoric acid. This approach enhances enantioselectivity while maintaining mild reaction conditions and broad substrate compatibility.

Mechanistic studies reveal the role of conformational distortion in catalyst efficiency. The method promises significant applications in asymmetric synthesis for pharmaceuticals and bioactive molecules.